Table 6 ROC curve for predicting the presence of CSPH in HCV-related liver cirrhosis
Variables | AUC | 95% CI | Sig. | Cutoff value | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|---|---|---|---|
Laboratory values | ||||||||
INR | 0.633 | 0.518 to 0.738 | 0.033 | >1.17 | 87.50% | 37.50% | 58.3 | 75 |
Platelet count | 0.887 | 0.797 to 0.947 | < 0.001 | ≤ 98 | 82.50% | 95% | 94.3 | 84.4 |
Noninvasive markers | ||||||||
Child-Pugh score | 0.897 | 0.809 to 0.954 | < 0.001 | > 6 | 85% | 100% | 100 | 87 |
PC/SD ratio | 0.909 | 0.824 to 0.962 | < 0.001 | ≤ 669 | 80% | 100% | 100 | 83.3 |
FIB-4 index | 0.665 | 0.551 to 0.767 | 0.008 | > 8.01 | 47.50% | 92.50% | 86.4 | 63.8 |
King’s score | 0.646 | 0.531 to 0.750 | 0.022 | > 57.95 | 62.50% | 72.50% | 69.4 | 65.9 |
Lok index | 0.637 | 0.522 to 0.742 | 0.03 | > 2.61 | 65% | 65% | 65 | 65 |
Portal vein duplex and spleen diameter | ||||||||
PVD | 0.949 | 0.875 to 0.986 | < 0.001 | > 13.8 | 82.50% | 95% | 94.3 | 84.4 |
PV velocity | 0.984 | 0.926 to 0.999 | < 0.001 | ≤ 16.5 | 100% | 85% | 87 | 100 |
Spleen diameter | 0.892 | 0.802 to 0.950 | < 0.001 | > 14.3 | 80% | 87.50% | 86.5 | 81.4 |