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Egyptian Liver Journal

Table 5 ROC curve analysis and optimal cutoff values of urinary biomarkers for stage 1 HRS-AKI in cirrhotic patients with ascites

From: Do old urinary biomarkers have a place in the new definition of hepatorenal syndrome in the Egyptian cirrhotic patients? A single-center experience

Variable

Optimal cutoff

Sensitivity

Specificity

PPV

NPV

AUC

P-value

95% CI

Accuracy

NGAL (pg/ml)

> 125

100

100

100

100

1

< 0.001*

0.96–1.0

100

IL18 (pg/ml)

> 34.8

51.72

76

55.6

73.1

0.641

0.037*

0.52–0.74

67.09

KIM 1 (pg/ml)

> 3.1

100

68

64.4

100

0.783

< 0.001*

0.68–0.86

79.75

  1. *Significant level at P value < 0.05
  2. Bold values indicate significant results
  3. NGAL Neutrophil gelatinase lipocalin, IL-18 Interleukin-18, KIM-1 Kidney injury molecule-1, AUC Area under the curve, 95% CI 95% confidence index, PPV Positive predictive value, NPV Negative predictive value
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