| |
Improved (n=64)
|
Deceased (n=185)
|
P
|
|---|
|
Age (years)
|
50.7 ± 12.1
|
55.0 ± 12.9
|
0.022
|
|
Total bilirubin (mg/dl)
|
20.8 ± 6.7
|
21.5 ± 7.0
|
0.482
|
|
Albumin (g/dl)
|
2.7 ± 0.6
|
2.3 ± 0.5
|
<0.0001
|
|
ALT (IU/l)
|
113.5 (19–1521)
|
148 (15–3850)
|
0.040
|
|
AST (IU/l)
|
83.5 (12–1937)
|
78 (6–3000)
|
0.877
|
|
ALP (IU/l)
|
164 (55–663)
|
149 (6–2080)
|
0.379
|
|
GGT (IU/l)
|
61 (15–1315)
|
57 (6-1549)
|
0.157
|
|
Hemoglobin (g/dl)
|
11.1 ± 1.8
|
10.7 ± 2.0
|
0.195
|
|
WBCs (×103/mm3)
|
11.3 ± 6.8
|
15.2 ± 7.7
|
<0.0001
|
|
Neutrophils (×103/mm3)
|
7.3 ± 4.1
|
12.5 ± 4.4
|
< 0.001
|
|
Platelets (×103/mm3)
|
163.9 ± 108.8
|
134.5 ± 89.3
|
0.034
|
|
INR
|
1.7 ± 0.6
|
2.2 ± 0.9
|
<0.0001
|
|
Creatinine (mg/dl)
|
1.4 ± 1.9
|
3.2 ± 2.0
|
<0.0001
|
|
ESR (mm/h)
|
14.3 ± 5.7
|
20.2± 5.7
|
< 0.001
|
|
CRP (mg/l)
|
15.2 ± 6.81
|
46.6 ± 5.4
|
< 0.001
|
|
NLR
|
2.2 ± 0.7
|
5.5 ± 1.6
|
< 0.001
|
|
Na (mEq/l)
|
132.4 ± 6.1
|
123.7 ± 8.6
|
<0.0001
|
|
MAP (mmHg)
|
79.7 ± 9.8
|
70.4 ± 15.7
|
<0.0001
|
|
Total ICU stay (days)
|
10.8 ± 6.4
|
6.8 ± 4.8
|
<0.0001
|
|
Total hospital stay (days)
|
11.9 ± 7.5
|
12 ± 7.8
|
0.937
|
|
Child-Pugh score
|
10.4 ± 1.2
|
12.3 ± 1.2
|
<0.0001
|
|
MELD
|
13.3 ± 2.6
|
18.7 ± 3.6
|
<0.0001
|
|
CLIF-C OF score
|
8.6 ± 1.2
|
11.3 ± 1.7
|
<0.0001
|
|
CLIF-C ACLF score
|
42.8 ± 8.2
|
55.6 ± 8.0
|
<0.0001
|
|
CLIF-C AD score
|
56.0 ± 12.1
|
76.1 ± 11.0
|
<0.0001
|
|
CLIF-SOFA score
|
7.1 ± 1.1
|
9.3 ± 1.8
|
<0.0001
|
- ACLF Acute-on-chronic liver failure, AD Acute decompensation, ALP Alkaline phosphatase, ALT Alanine aminotransferase, AST Aspartate aminotransferase, BP Blood pressure, CLIF-C Chronic liver failure consortium, GGT Gamma-glutamyl transferase, ICU Intensive care unit, ESR Erythrocyte sedimentation rate, CRP C-reactive protein, NLR Neutrophil-lymphocyte ratio, MAP Mean arterial pressure, MELD Model for end-stage liver disease, Na Sodium, OF Organ failure, PaO2 Partial pressure of arterial oxygen, SOFA Sequential organ failure assessment, WBCs White blood cells
