Parameter | Non-responders N = 3 | Relapsers N = 3 | Discontinued due to adverse events N = 9 | P value |
---|---|---|---|---|
Age (years) | ||||
Mean ± SD | 56.33 ± 6.66 | 51.33 ± 8.13 | 60.44 ± 6.24 | 0.18 |
(Min–Max) | (49–62) | (41–61) | (52–70) | |
Gender | ||||
Male | 1(33.3%) | 2(66.7%) | 6(66.7%) | 0.57 |
Female | 2(66.7%) | 1(33.3%) | 3(33.3%) | |
Prior HCV treatment | ||||
Naïve | 2(66.7%) | 3(100%) | 7(77.8%) | 0.57 |
Experienced | 1(33.3%) | 0(0%) | 2(22.2%) | |
Laboratory data | ||||
Hemoglobin (gm/dl) | 13.3 ± 2.3 | 12.73 ± 1.11 | 11.36 ± 1.32 | 0.14 |
Male: (13.2–17.5 gm/dl) | ||||
Female: (11.5–16 gm/dl) | ||||
WBCs × 103/ml (4–11 × 103/ml) | 3.3 ± 0.36 | 5.7 ± 2.1 | 3.26 ± 1.12 | 0.035 |
Platelet count × 103/ml (150–450 × 103/ml) | 58 (58–100) | 84 (74–111) | 111 (55–142) | 0.33 |
PCR (IU/ml) × 103 | 4780 (216.218–4823) | 1210 (393–1490) | 429 (10.780–1603.390) | 0.19 |
ALT/ULN (fold) | 1.05 (0.78–4.12) | 1.03 (0.8–1.24) | 0.93 (0.48–2.85) | 0.49 |
AST/ULN (fold) | 1.62 (1.03–4.7) | 1.85 (1.38–3.41) | 1.73 (0.4–3.46) | 0.91 |
Serum albumin (g/dl) (3.4–5.4 g/dl) | 3 ± 0.26 | 2.53 ± 0.25 | 2.8 ± 0.24 | 0.10 |
Serum bilirubin (mg/dl) (0.3–1 mg/dl) | 1.77 ± 0.6 | 2.3 ± 0.79 | 1.54 ± 1 | 0.48 |
I.N.R. (0.9–1.2) | 1.42 ± 0.28 | 1.42 ± 0.14 | 1.3 ± 0.18 | 0.53 |
Serum creatinine (mg/dl) | ||||
Male: (0.6–1.2 mg/dl) | 0.6 ± 0.1 | 0.87 ± 0.4 | 1.17 ± 0.4 | 0.09 |
Female: (0.8–1.4 mg/dl) | ||||
AFP (μg/l) (< 8 μg/l) | 12 (6.5–83) | 10.2 (9–20.7) | 7.6 (2.64–25) | 0.37 |
MELD score | ||||
Median | 12 | 14 | 13 | |
(Min–max) | (11–13) | (11–17) | (8–18) | 0.62 |
< 10 | 0(0%) | 0(0%) | 2(22.2%) | 0.46 |
≥ 10 | 3(100%) | 3(100%) | 7(77.8%) | |
Ultrasonographic features | ||||
Liver cirrhosis | 3(100%) | 3(100%) | 9(100) | P = 1.0 |
Splenomegaly | 1(33.3%) | 1(33.3%) | 4(44.4%) | P = 0.9 |
Ascites | 1(33.3%) | 1(33.3%) | 9(100%) | P = 0.02 |
Hemangioma | 1(33.3%) | 0(0%) | 0(0%) | P = 0.12 |
Ablated HCC | 0(0%) | 0(0%) | 0(0%) | |
Child-Pugh score | ||||
B7 | 3(100%) | 1(33.3%) | 2(22.2%) | 0.19 |
B8 | 0(0%) | 1(33.3%) | 5(55.6%) | |
B9 | 0(0%) | 1(33.3%) | 2(22.2%) |