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Table 2 Liver outcome in severe and non-severe COVID-19 patients

From: Liver injury with COVID-19: laboratory and histopathological outcome—systematic review and meta-analysis

  Sample size Number of patients with abnormal liver function Patients with pre-existing liver conditions Positive liver histopathology findings
Total patients Non-severe COVID Severe COVID Total patients Non-severe COVID Severe COVID Total Non-severe Severe
Cai et al. [12] 417 318 (76.3%) 233 (71.5%) 85 (93.4%) 21 (5%) nd nd nd   
Chen et al. [13] 274 84 (31) 25 (16) 59 (52%) nd    nd   
Guan et al. [14] 1099 168/77 (22.2%) 112/615 (18.2%) 56/142 (39.4%) 23 (2.1) 22 (2.4%) 1 (0.6) nd   
Huang et al. [15] 41 15 (31%) 7/25 (25%) 8/13 (62%) 1 (2.0%) 1 (4%) 0 nd   
Lagana et al. [16] 40 40 (100%)   40 (100%) 2/16 (13%)   2/16 (13%) 40 100%   40 100%
Shi et al. [17] 81 43 (53%) 4 (27%) 13 (62%) 7 (9%) 0 2 (10%) nd   
Sonzogni et al. [18] 48 (40/41) 97.6%   (40/4) 97.6% nd    48 100%   48 100%
Tian et al. [19] 4 1 0 1 1 0 1 1 25% 0 1 100%
Wander et al. [20] 1 1   1 nd    nd   
Xie et al. [21] 79 35% 13% 77.80% nd    nd   
Xu et al. [22] 1 1 0 1 nd    1 100% 0 1 100%
Xu et al. [23] 62 10 (16%) 5 (17%) 5(15%) 7 (11) 3 (10%) 4 (12%) nd   
Yang et al. [24] 52 15 (29%) 28% 30% nd nd nd nd   
Zhang et al. [25] 645 81 6 (8.3%) 75 (13.1%) 25 2 (2.8%) 23 (4.0%) nd   
Zhao et al. [26] 91 18 (19.8%) 5/61 (16.4%) 8/30 (26.7%) nd    nd   
  1. nd no data available