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Table 1 Hepatologists’ attitude towards the use of liver biopsy for diagnosis of significant fibrosis and cirrhosis

From: Role of liver biopsy versus non-invasive biomarkers for diagnosis of significant fibrosis and cirrhosis: a web-based survey

Variable Patients (n = 573)
Do you think the liver biopsy is still the gold standard for diagnosing liver fibrosis? %
 Extremely likely (100%) 21.15
 Very likely (75%) 39.92
 Moderately likely (50%) 23.91
 Slightly likely (25%) 11.07
 Not at all likely (0%) 3.95
In your practice what percentage of patients accept liver biopsy? %
 Extremely likely (100%) 6.13
 Very likely (75%) 37.55
 Moderately likely (50%) 32.81
 Slightly likely (25%) 22.53
 Not at all likely (0%) 1.98
Do you think we still need a liver biopsy for the diagnosis of significant fibrosis and cirrhosis in viral hepatitis? %
 Extremely likely (100%) 4.35
 Very likely (75%) 13.64
 Moderately likely (50%) 26.88
 Slightly likely (25%) 37.94
 Not at all likely (0%) 18.18
Do you think we still need a liver biopsy for the diagnosis of significant fibrosis and cirrhosis in non-viral chronic liver diseases? %
 Extremely likely (100%) 10.67
 Very likely (75%) 34.39
 Moderately likely (50%) 27.67
 Slightly likely (25%) 20.55
 Not at all likely (0%) 7.11
How frequently do you see discordant results of liver biopsy histopathology reports with clinical findings? %
 Extremely likely (100%) 0.99
 Very likely (75%) 6.52
 Moderately likely (50%) 30.24
 Slightly likely (25%) 59.68
 Not at all likely (0%) 2.57
What do you do if the histopathology report is discordant with clinical findings? %
 Ask for a second opinion from another pathologist 34.19
 Repeat liver biopsy 6.72
 Use non-invasive methods “biomarkers” 19.57
 Use non-invasive methods “Radiological” 39.53
Do you think that currently used histopathological scoring systems are satisfactory for clinical decisions? %
 Extremely likely (100%) 9.29
 Very likely (75%) 59.88
 Moderately likely (50%) 25.30
 Slightly likely (25%) 4.94
 Not at all likely (0%) 0.59
Do you diagnose cirrhosis easily? %
 Yes 88.45
 No 11.55
How do you diagnose cirrhosis? “choose all that apply” %
 Clinically 51.58
 Laboratory tests 50
 Radiological methods 53.95
 All of the above 62.85
Do you diagnose significant fibrosis easily? %
 Yes 51.58
 No 48.42
How do you diagnose significant fibrosis? “choose all that apply” %
 Clinically 22.92
 Laboratory tests 34.19
 Radiological methods 44.66
 All of the above 38.93
Do you think a liver biopsy is required for diagnosing cirrhosis? %
 Extremely likely (100%) 2.77
 Very likely (75%) 8.50
 Moderately likely (50%) 21.94
 Slightly likely (25%) 45.45
 Not at all likely (0%) 21.34
Do you think we need a more practical alternative to liver biopsy to assess liver disease progression or response to treatment? %
 Extremely likely (100%) 47.83
 Very likely (75%) 36.17
 Moderately likely (50%) 10.08
 Slightly likely (25%) 4.15
 Not at all likely (0%) 1.78