Novel biomarkers assist in detection of liver fibrosis in HCV patients

Egyptian Liver Journal

Table 1 Presentation of sensitivity and specificity and accuracy of serum biomarkers levels and fibrosis scoring systems to discriminate liver fibrosis from control curve in HCV patients

	AUC	p	95% CI		Cutoff	Sensitivity	Specificity	PPV	NPV	Accuracy
	AUC	p	LL	UL	Cutoff	Sensitivity	Specificity	PPV	NPV	Accuracy
H.A	0.998^*	<0.001^*	0.994	1.00	>46	96.72	98.67	98.3	97.4	97.79
CO IV (μg/L)	0.863^*	<0.001^*	0.795	0.932	>98.1	77.05	100.0	100.0	84.3	89.71
COMP (μg/mL)	0.977^*	<0.001^*	0.953	1.002	>15	91.80	100.0	100.0	93.7	96.32
APRI	0.733^*	<0.001^*	0.625	0.842	>0.25	72.13	97.33	95.7	81.1	86.03
SHASTA	0.990^*	<0.001^*	0.980	1.001	>-2.14	91.80	88.0	86.2	93.0	89.71
NAFLD	1.000^*	<0.001^*	1.000	1.000	>-1.645	100.0	100.0	100.0	100.0	100.0
FIB-4	0.974^*	<0.001^*	0.949	1.000	>0.9	91.80	100.0	100.0	93.7	96.32