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Table 3 Comparison between the histopathological degree of fibrosis and non-invasive fibrosis scores (APRI and FIB-4) and serum MMP-1 level in chronic liver disease patients

From: Matrix metalloproteinase-1 as a non-invasive biomarker to assess liver fibrosis in children with chronic liver disease

Degree of fibrosis APRI FIB-4 MMP-1 (ng\ml)
F1 (n = 67) 0.70 ± 0.5 0.26 ± 0.13 19.2 ± 1.5
F2 (n = 27) 0.74 ± 0.59 0.33 ± 0.19 13.1 ± 0.7
F3 (n = 10) 2.3 ± 0.38 0.85 ± 0.54 8.8 ± 0.4
F4 (n = 16) 2.55 ± 0.02 2.01 ± 0.04 6.2 ± 0.5
F value 74.5 164.7 24.5
P 0.001 0.001 0.001
  1. Data represented as mean ± SD
  2. F one-way ANOVA, APRI aspartate aminotransferase to platelet ratio index, FIB-4 fibrosis-4 index, F F value in ANOVA test