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Egyptian Liver Journal

Table 3 Comparison between the histopathological degree of fibrosis and non-invasive fibrosis scores (APRI and FIB-4) and serum MMP-1 level in chronic liver disease patients

From: Matrix metalloproteinase-1 as a non-invasive biomarker to assess liver fibrosis in children with chronic liver disease

Degree of fibrosis

APRI

FIB-4

MMP-1 (ng\ml)

F1 (n = 67)

0.70 ± 0.5

0.26 ± 0.13

19.2 ± 1.5

F2 (n = 27)

0.74 ± 0.59

0.33 ± 0.19

13.1 ± 0.7

F3 (n = 10)

2.3 ± 0.38

0.85 ± 0.54

8.8 ± 0.4

F4 (n = 16)

2.55 ± 0.02

2.01 ± 0.04

6.2 ± 0.5

F value

74.5

164.7

24.5

P

0.001

0.001

0.001

  1. Data represented as mean ± SD
  2. F one-way ANOVA, APRI aspartate aminotransferase to platelet ratio index, FIB-4 fibrosis-4 index, F F value in ANOVA test
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