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Table 2 KIR frequencies in type I AIH and healthy individuals

From: Association of the killer immunoglobulin-like receptor genes KIR2DS1 and KIR2DS4 with pediatric autoimmune hepatitis type I in Egypt

KIR genes

AIH-I

Controls

P

OR (95% CI)

(n = 80)

(n = 80)

KIR2DS1

+

68 (85)

24 (30)

< 0.001

13.22 (6.07–28.79)

−

12 (15)

56 (70)

KIR2DS4

+

74 (92.5)

50 (62.5)

< 0.001

7.4 (2.87–19.08)

−

6 (7.5)

30 (37.5)

 

(n = 74)

(n = 50)

  

KIR2DS4 alleles

  

 KIR2DS4-FL

56 (75.7)

10 (20)

0.002

12.44 (5.2–29.79)

 KIR1D

18 (24.3)

40 (80)

KIR2DS4 variants

 Homozygous (full/full)

34 (45.94)

6 (12)

0.003

10.7 (3.79–30.25)

 Heterozygous (full/del)

22 (29.73)

10 (20)

4.16 (1.62–10.65)

 Homozygous (del/del)

18 (24.33)

34 (68)

R

KIR haplotypes

(n = 80)

(n = 80)

  

 KIR AA

12 (15)

56 (70)

< 0.001

13.22 (6.07–28.79)

 KIR Bx (KIR AB and BB)

68 (85)

24 (30)

  1. Data are given as number (%)
  2. +, present gene; −, absent gene; KIR1D, 22 bp deletion variant of KIR2DS4-full length; R, reference genotype