Role of bile acids in the prediction of hepatocellular carcinoma in HCV-induced liver cirrhosis

Egyptian Liver Journal

Table 4 Bile acids correlation analysis with AFP and their multivariate analysis with HCC clinical parameters

BA	Pearson Correlation	Multivariate analysis, F test
BA	AFP	# FL	LN	Met	CHP-S	B. stage
CA	0.29*	0.40 ^NS	0.07 ^NS	1.03 ^NS	2.39 ^NS	0.71 ^NS
CDCA	0.01 ^NS	0.07 ^NS	0.13 ^NS	1.27 ^NS	3.21*	0.12 ^NS
DCA	− 0.04 ^NS	1.82 ^NS	3.88 ^NS	0.39 ^NS	1.62 ^NS	4.02*
LCA	0.13*	1.40 ^NS	1.75 ^NS	1.34 ^NS	0.46 ^NS	0.45 ^NS
UDCA	− 0.02 ^NS	1.53 ^NS	0.16 ^NS	0.91 ^NS	2.34 ^NS	0.03 ^NS
GCA	0.04 ^NS	0.76 ^NS	0.10 ^NS	0.26 ^NS	28.15*	0.45 ^NS
GCDCA	0.08 ^NS	0.01 ^NS	0.00 ^NS	0.11 ^NS	2.38 ^NS	0.37 ^NS
GDCA	− 0.01 ^NS	0.29 ^NS	0.34 ^NS	5.07*	1.33 ^NS	0.58
GUDCA	0.06 ^NS	0.77 ^NS	0.14 ^NS	0.48 ^NS	2.67*	0.29 ^NS
TCA	0.10*	0.12 ^NS	0.41 ^NS	0.31 ^NS	14.90*	2.49 ^NS
TCDCA	0.07 ^NS	0.08 ^NS	0.30 ^NS	0.20 ^NS	0.61 ^NS	0.62 ^NS
TDCA	− 0.01 ^NS	1.63 ^NS	0.02 ^NS	0.13 ^NS	0.18 ^NS	18.14*
TLCA	0.13*	4.46*	7.14*	1.26 ^NS	1.38 ^NS	4.44*
TUDCA	0.66*	0.00^NS	0.00 ^NS	0.00 ^NS	4.11*	0.00 ^NS

BA bile acid, HCC hepatocellular carcinoma, N = 50; FL number of focal lesions, LN lymph node, Met metastasis, CHP-S Child-Pugh Score, B. stage Barcelona stage of HCC, * indicates P value < 0.05 and presence of a significant correlation. ^NS indicates P value > 0.05 and absence of a significant correlation
CA cholic acid, CDCA chenodeoxycholic acid, DCA deoxycholic acid, LCA lithocholic acid, UDCA ursodeoxycholic acid, GCA glycholic acid, GCDCA glycochenodeoxycholic acid, GDCA glycodeoxycholic acid, GUDCA glycoursodeoxycholic acid, TCA taurocholic acid, TCDCA taurochenodeoxycholic acid, TDCA taurodeoxycholic acid, TLCA taurolithocholic acid, TUDCA tauroursodeoxycholic acid