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Table 1 Demographic, clinical, and hematological parameter of the enrolled groups

From: Role of bile acids in the prediction of hepatocellular carcinoma in HCV-induced liver cirrhosis

  NHC NCLD CLD HCC
Age, mean (range) 45 (34–73) 46 (36–69)NS 46 (37–70)NS 46 (37–69)NS
BMI (kg/m2) 23.5 ± 0.4 23.6 ± 0.3NS 22.9 ± 0.3NS 23.4 ± 0.3NS
Sex
 Male 25 (50%) 19 (38%) 29 (58%) 15 (30%)
 Female 25 (50%) 31 (62%) 21 (42%) 35 (70%)
AFP ng/ml, median (IQR) 1.7 (0.8) 2.3 (1.2) NS 3.7 (4.4)* 68.4 (877)*
Child-Pugh class, A/B/C    38 (76%)/8 (16%)/4 (8%) 18 (36%)/17 (34%)/15 (30%)
HFL, single/multiple     19 (38%)/31 (62%)
Metastasis, No/Yes     46 (92%)/4 (8%)
Lymph node, No/yes     43 (86%)/7 (14%)
PV invasion, No/yes     50 (100%)/0 (0%)
Barcelona, HCC stage A/B/C     36 (72%)/10 (20%)/4 (8%)
AST (IU/L) 20.7 ± 6.5 39.8 ± 34.4* 56.6 ± 35* 55.4 ± 29.2*
ALT (IU/L) 20.2 ± 8.6 41.3 ± 36.7* 41.9 ± 44.2* 31.9 ± 18.5*
GGT (IU/ml) 23 ± 13 35 ± 22* 71 ± 53* 73 ± 61*
ALP (IU/ml) 60.3 ± 22.6 74.5 ± 47 NS 113.5 ± 57* 117.2 ± 49.2*
TBil (mg/dl) 0.5 ± 0.2 0.6 ± 0.3* 1.5 ± 1.6* 1.5 ± 1.2*
DBil (mg/dl) 0.2 ± 0.1 0.2 ± 0.1 NS 1.2 ± 1.7* 0.8 ± 0.7*
ALB (g/dl) 4 ± 0.2 4.7 ± 0.3 3.5 ± 0.8* 3.3 ± 0.7*
TP (mg/dl) 7 ± 0.9 8 ± 0.4 NS 8 ± 0.7 NS 7 ± 0.7*
Hb ( g/l ) 134 ± 12 131 ± 15 NS 119.8 ± 20* 120 ± 20*
Platelets x (109/l) 290.9 ± 72.2 259 ± 91 NS 132.3 ± 63.8* 128.7 ± 63.1*
WBCs x (109/l) 7.3 ± 1.4 6.9 ± 1.5 NS 5.4 ± 2.3* 5 ± 1.9*
  1. NHC normal healthy control, CLD cirrhotic liver diseases, HCC hepatocellular carcinoma. N = 50 for each group, value = mean ± standard deviation, median; IQR interquartile range, *P value < 0.05 indicates significance when NHC compared to NCLD, CLD, and HCC. NSP value > 0.05 indicates non significance when NHC compared to NCLD, CLD, and HCC. BMI body mass index, HFL hepatic focal lesion, PV portal vein, AST aspartate transaminase, ALT alanine transaminase, GGT gamma-glutamyl transferase, ALP alkaline phosphatase, TBil total bilirubin, DBiL direct bilirubin, TP total protein, Alb albumin, Hb hemoglobin, WBCs white blood cells