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Table 1 Demographic, clinical, and hematological parameter of the enrolled groups

From: Role of bile acids in the prediction of hepatocellular carcinoma in HCV-induced liver cirrhosis

 

NHC

NCLD

CLD

HCC

Age, mean (range)

45 (34–73)

46 (36–69)NS

46 (37–70)NS

46 (37–69)NS

BMI (kg/m2)

23.5 ± 0.4

23.6 ± 0.3NS

22.9 ± 0.3NS

23.4 ± 0.3NS

Sex

 Male

25 (50%)

19 (38%)

29 (58%)

15 (30%)

 Female

25 (50%)

31 (62%)

21 (42%)

35 (70%)

AFP ng/ml, median (IQR)

1.7 (0.8)

2.3 (1.2) NS

3.7 (4.4)*

68.4 (877)*

Child-Pugh class, A/B/C

  

38 (76%)/8 (16%)/4 (8%)

18 (36%)/17 (34%)/15 (30%)

HFL, single/multiple

   

19 (38%)/31 (62%)

Metastasis, No/Yes

   

46 (92%)/4 (8%)

Lymph node, No/yes

   

43 (86%)/7 (14%)

PV invasion, No/yes

   

50 (100%)/0 (0%)

Barcelona, HCC stage A/B/C

   

36 (72%)/10 (20%)/4 (8%)

AST (IU/L)

20.7 ± 6.5

39.8 ± 34.4*

56.6 ± 35*

55.4 ± 29.2*

ALT (IU/L)

20.2 ± 8.6

41.3 ± 36.7*

41.9 ± 44.2*

31.9 ± 18.5*

GGT (IU/ml)

23 ± 13

35 ± 22*

71 ± 53*

73 ± 61*

ALP (IU/ml)

60.3 ± 22.6

74.5 ± 47 NS

113.5 ± 57*

117.2 ± 49.2*

TBil (mg/dl)

0.5 ± 0.2

0.6 ± 0.3*

1.5 ± 1.6*

1.5 ± 1.2*

DBil (mg/dl)

0.2 ± 0.1

0.2 ± 0.1 NS

1.2 ± 1.7*

0.8 ± 0.7*

ALB (g/dl)

4 ± 0.2

4.7 ± 0.3

3.5 ± 0.8*

3.3 ± 0.7*

TP (mg/dl)

7 ± 0.9

8 ± 0.4 NS

8 ± 0.7 NS

7 ± 0.7*

Hb ( g/l )

134 ± 12

131 ± 15 NS

119.8 ± 20*

120 ± 20*

Platelets x (109/l)

290.9 ± 72.2

259 ± 91 NS

132.3 ± 63.8*

128.7 ± 63.1*

WBCs x (109/l)

7.3 ± 1.4

6.9 ± 1.5 NS

5.4 ± 2.3*

5 ± 1.9*

  1. NHC normal healthy control, CLD cirrhotic liver diseases, HCC hepatocellular carcinoma. N = 50 for each group, value = mean ± standard deviation, median; IQR interquartile range, *P value < 0.05 indicates significance when NHC compared to NCLD, CLD, and HCC. NSP value > 0.05 indicates non significance when NHC compared to NCLD, CLD, and HCC. BMI body mass index, HFL hepatic focal lesion, PV portal vein, AST aspartate transaminase, ALT alanine transaminase, GGT gamma-glutamyl transferase, ALP alkaline phosphatase, TBil total bilirubin, DBiL direct bilirubin, TP total protein, Alb albumin, Hb hemoglobin, WBCs white blood cells