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Table 7 C/D ratio in correlation with different genotype of donor when recipient genotype is CC (Mann–Whitney test)

From: Clinical utility of ABCB1 single nucleotide polymorphism on tacrolimus dose requirements in Egyptian liver transplant patients

  Group 1 (CC/CC) Group 2 (CC/CT or TT) U test P-value Sig.
No. = 7 No. = 4
1st wk       
C/D ratio Median (IQR) 44.1(34.5–70) 113(74–173.5) −2.268 0.023 S
Range 32–75.2 48–221
Dose Median (IQR) 0.07(0.05–0.09) 0.07(0.02–0.4) 0.000 1.000 NS
Range 0.05–0.1 0.01–0.7
Trough level Median (IQR) 4.14(2.4–4.4) 3.55(1.4–6.05) −0.189 0.850 NS
Range 1.6–4.9 1–6.8
2nd wk       
C/D Median (IQR) 92.5(66.3–122.4) 65.45(55.25–94.33) −1.323 0.186 NS
Range 66–170 54.5–113.75
Dose Median (IQR) 0.06(0.04–0.08) 0.08(0.06–2.05) −1.245 0.213 NS
Range 0.03–0.08 0.05–4
Trough level Median (IQR) 4.2(3.7–8.4) 4.78(3.63–5.3) −0.379 0.705 NS
Range 3.7–8.5 2.8–5.5
3rd wk       
C/D Median (IQR) 78(53.6–112) 125.3(82.5–157.3) −1.136 0.256 NS
Range 38.16–116 60–169
Dose Median (IQR) 0.06(0.04–0.09) 0.07(0.04–2.64) −0.190 0.849 NS
Range 0.02–0.1 0.02–5.2
Trough level Median (IQR) 5.2(3.6–6.5) 5.2(3.88–8.1) 0.000 1.000 NS
Range 3.3–9 3.16–10.4
4th wk       
C/D Median (IQR) 99.5(63–141) 107.35(85.1–285.75) −0.756 0.450 NS
Range 62.1–167 79–448
Dose Median (IQR) 0.05(0.04–0.09) 0.04(0.02–2.28) −0.579 0.563 NS
Range 0.04–0.2 0.02–4.5
Trough level Median (IQR) 5.85(5.2–6.5) 3.51(2.13–5.14) −1.492 0.136 NS
Range 3–7.75 1.4–6.1
2 months       
Dose Median (IQR) 0.1(0.04–0.1) 0.09(0.07–0.1) −0.232 0.817 NS
Range 0.04–0.1 0.07–0.1
Trough level Median (IQR) 5.9(2.9–10.6) 4.7(3.8–12.9) −0.218 0.827 NS
Range 2.9–10.6 3.8–12.9
C/D Median (IQR) 73(49–106) 54(47–143) −0.218 0.827 NS
Range 49–106 47–143
3 months       
Dose Median (IQR) 0.05(0.02–0.07) 0.09(0.08–0.1) −1.964 0.050 NS
Range 0.02–0.07 0.08–0.1
Trough level Median (IQR) 5(4.5–8.8) 4.9(3.2–7.4) −0.655 0.513 NS
Range 4.5–8.8 3.2–7.4
C/D Median (IQR) 176(71–225) 61(32–82) −1.528 0.127 NS
Range 71–225 32–82
  1. P > 0.05, non-significant; P < 0.05, significant; P < 0.01, highly significant