Table 3 Agreement (sensitivity, specificity) for AFP, miR-331-3p, and miR-23b-3p for diagnosing early-stage HCC patients

AFP (ng/ml)

0.665

0.001*

0.557–0.772

> 148

64.0

61.0

45.1

77.2

miR-331-3p

0.703

< 0.001*

0.602–0.803

> 2.18

66.0

61.0

45.8

78.2

miR-23b-3p

0.781

< 0.001*

0.706–0.856

≤ 0.36

80.0

74.0

60.6

88.1

AFP (ng/ml) and miR-331-3p

0.773

< 0.001*

0.678–0.868

76.0

65.0

52.1

84.4

AFP (ng/ml) and miR-23b-3p

0.814

< 0.001*

0.746–0.883

82.0

69.0

56.9

88.5

AFP (ng/ml) and miR-331-3p and miR-23b-3p

0.854

< 0.001*

0.791–0.916

86.0

64.0

54.4

90.1