Skip to main content

Table 3 Agreement (sensitivity, specificity) for AFP, miR-331-3p, and miR-23b-3p for diagnosing early-stage HCC patients

From: The expression of microRNA-331-3p and microRNA-23b3 in Egyptian patients with early-stage hepatocellular carcinoma in hepatitis C-related liver cirrhosis

  AUC p 95% CI Cut-off Sensitivity Specificity PPV NPV
AFP (ng/ml) 0.665 0.001* 0.557–0.772 > 148 64.0 61.0 45.1 77.2
miR-331-3p 0.703 < 0.001* 0.602–0.803 > 2.18 66.0 61.0 45.8 78.2
miR-23b-3p 0.781 < 0.001* 0.706–0.856 ≤ 0.36 80.0 74.0 60.6 88.1
AFP (ng/ml) and miR-331-3p 0.773 < 0.001* 0.678–0.868   76.0 65.0 52.1 84.4
AFP (ng/ml) and miR-23b-3p 0.814 < 0.001* 0.746–0.883   82.0 69.0 56.9 88.5
AFP (ng/ml) and miR-331-3p and miR-23b-3p 0.854 < 0.001* 0.791–0.916   86.0 64.0 54.4 90.1
  1. AUS area under a curve, NPV negative predictive value, p value probability value, PPV positive predictive value, CI confidence intervals
  2. *Statistically significant at p ≤ 0.05