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Table 1 Comparison between the three studied groups according to the demographic data, laboratory investigations, and serum concentrations of miR-331-3p and miR-23b-3p

From: The expression of microRNA-331-3p and microRNA-23b3 in Egyptian patients with early-stage hepatocellular carcinoma in hepatitis C-related liver cirrhosis

  Group I (HCV-related liver cirrhosis) (n = 100) Group II (HCC group) (n = 50) (16 stage 0 BCLC, 34 stage A BCLC) Group III (healthy controls) (n = 50) Test of Sig. p
Age (years)
 Mean ± SD 47.4 ± 9.7 50.6 ± 5.2 47.5 ± 9.3 F = 2.489 0.086
 Median (min.–max.) 49(25–61) 51(41–59) 48(32–63)
Gender
 Male 79 (79%) 40 (80%) 35 (70%) χ2 = 1.863 0.394
 Female 21 (21%) 10 (20%) 15 (30%)
ALT (IU/L)
 Mean ± SD 59.7 ± 35.1 60.4 ± 26.3 19.0 ± 7.7 H = 72.496* < 0.001*
 Median (min.–max.) 56.5a (8.4–165) 48a (33–127) 18.4b (5.8–38.1)
AST (IU/L)
 Mean ± SD 53.2 ± 30.1 55.3 ± 24.8 18.7 ± 6.3 H = 84.833* < 0.001*
 Median (min.–max.) 45.5a (6.9–155) 44.5a (30–119) 17.6b (6.4–30.2)
Total bilirubin (mg/dl)
 Mean ± SD 1.2 ± 0.6 1.1 ± 0.4 0.7 ± 0.3 H = 25.660* < 0.001*
 Median (min.–max.) 1.1a (0.2–2.8) 1a (0.4–2) 0.8b (0.1–1.2)
Albumin (g/dl)
 Mean ± SD 3.9b ± 3.1 3.6c ± 2.6 4.3a ± 4.8 F = 46.804* < 0.001*
 Median (min.–max.) 4.0 (3.3–4.5) 3.6 (3.2–4.0) 4.2 (3.4–5.2)
Hemoglobin (g/dl)
 Mean ± SD 13.6a ± 1.8 12.2b ± 1.3 14.1a ± 1.1 F = 22.005* < 0.001*
 Median (min.–max.) 13.9 (8.5–16.4) 12.0 (10.0–15.0) 14.4 (12.1–15.9)
Total leukocytic count (× 109)
 Mean ± SD 5.2b ± 1 4.2c ± 1.1 6.7a ± 1.8 F = 51.129* < 0.001*
 Median (min.–max.) 5.1 (3.5–7.1) 4 (2.4–6.3) 6.5 (4.3–10.2)
Platelet count (× 109)
 Mean ± SD 160.9a ± 46.8 130.2c ± 21.5 223.1b ± 44.1 F = 67.135* < 0.001*
 Median (min.–max.) 158 (63–254) 134.5 (91–162) 238.5 (126–358)
AFP (ng/ml)
 Mean ± SD 140.3 ± 45.2 183.1 ± 77 1.0 ± 0.4 H = 117.964* < 0.001*
 Median (min.–max.) 138b (1.8–240) 196a (58–287) 1c (0.2–1.9)
miR-331-3p (2−∆CT)
 Mean ± SD 2.2 ± 1.3 7.6 ± 10 1.1 ± 0.5 H = 69.738* < 0.001*
 Median (min.–max.) 1.98b (0.1–7.8) 3.8a (0.1–41) 1c (0.1–3.2)
miR-23b-3p (2−∆CT)
 Mean ± SD 0.9 ± 0.8 0.3 ± 0.3 1.5 ± 1.1 H = 54.230* < 0.001*
 Median (min.–max.) 0.8b (− 0.98 to 3.2) 0.2c (0–1.7) 1.3a (− 1 to 3.8)
  1. χ2 chi-square test, F F for ANOVA test, H H for Kruskal-Wallis test, p p-value for comparing between the studied groups
  2. Means/median with common letters are not significant (i.e., means with different letters are significant)
  3. *Statistically significant at p ≤ 0.05