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Table 2 Genotypes distribution and allele frequencies of polymorphism -589 C/T (rs2243250) in control, cirrhotic, and HCC groups

From: The role of IL-4 gene polymorphism in HCV-related hepatocellular carcinoma in Egyptian patients

polymorphism -589 C/T (rs2243250) Control
n = 30(%)
LC
n = 40 (%)
HCC
n = 50 (%)
p value LC vs control HCC vs. control HCC vs. LC
OR (95% CI) P value OR (95% CI) P value OR (95% CI) p value
Genotypes   0.044       
CC 15 (50.0) 19 (47.5) 18 (36.0)   Ref Ref Ref
CT 14 (46.7) 19 (47.5) 20 (40.0)   1.07 (0.41–2.82) 0.889 1.19 (0.45–3.13) 0.724 1.11 (0.45–2.73) 0.818
TT 1 (3.3) 2 (5.0) 12 (24.0)   1.58 (0.13–19.12) 1.000 10.0 (1.16–86.02) 0.018 6.33 (1.24–32.32) 0.016
Dominant model     0.391       
CC 15 (50.0) 19 (47.5) 18 (36.0)   Ref Ref Ref
CT+TT 15 (50.0) 21 (52.5) 32 (64.0)   1.11 (0.43–2.85) 0.836 1.78 (0.71–4.46) 0.218 1.61 (0.69 – 3.76) 0.271
Recessive model     0.008       
CC+CT 29 (96.7) 38 (96.0) 38 (76.0)   Ref Ref Ref
TT 1 (3.3) 2 (5.0) 12 (24.0)   1.53 (0.13–17.66) 1.000 9.16 (1.13–74.52) 0.025 6.00 (1.26–28.64) 0.013
Alleles     0.034       
C 44 (73.3) 57 (71.3) 56 (56.0)   Ref Ref Ref
T 16 (26.7) 23 (28.8) 44 (44.0)   1.11 (0.52–2.35) 0.786 2.16 (1.08–4.33) 0.028 1.95 (1.04–3.64) 0.035
  1. Data are n (%), CI confidence interval, significant p value < 0.05