Table 5 Diagnostic performance of GDF-15 as a marker of liver fibrosis for discriminating different groups
GDF-15(ng/L) for discriminating HCV patients’ group from the control group | Cut-off | Sensitivity (%) | Specificity (%) | NPV (%) | PPV (%) | EFF (%) | AUC |
150 | 96.7 | 98.2 | 96.7 | 98.2 | 97.6 | 0.99 | |
GDF-15(ng/L) for discriminating subgroup I patients from control group | Cut-off | Sensitivity (%) | Specificity (%) | NPV (%) | PPV (%) | EFF (%) | AUC |
150 | 100 | 96.7 | 100 | 94.7 | 97.9 | 0.798 | |
GDF-15(ng/L) for discriminating subgroup І (F0–F1) patients from subgroup II (F2) | Cut-off | Sensitivity (%) | Specificity (%) | NPV (%) | PPV (%) | EFF (%) | AUC |
400 | 66.7 | 76.9 | 80.8 | 62.5 | 71.0 | 0.694 | |
GDF-15(ng/L) for discriminating subgroup І (F0–F1) patients from subgroup III (F3–4) | Cut-off | Sensitivity (%) | Specificity (%) | NPV (%) | PPV (%) | EFF (%) | AUC |
220 | 27.8 | 95.8 | 83.3 | 63.9 | 66.7 | 0.687 | |
GDF-15(ng/L) for discriminating subgroup II (F2) patients from subgroup III (F3–F4). | Cut-off | Sensitivity (%) | Specificity (%) | NPV (%) | PPV (%) | EFF (%) | AUC |
420 | 54.2 | 69.2 | 76.5 | 45.0 | 59.5 | 0.508 |