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Table 5 Diagnostic performance of GDF-15 as a marker of liver fibrosis for discriminating different groups

From: Growth differentiation factor 15: an emerging diagnostic biomarker of liver fibrosis in chronic hepatitis C patients

GDF-15(ng/L) for discriminating HCV patients’ group from the control group Cut-off Sensitivity (%) Specificity (%) NPV (%) PPV (%) EFF (%) AUC
150 96.7 98.2 96.7 98.2 97.6 0.99
GDF-15(ng/L) for discriminating subgroup I patients from control group Cut-off Sensitivity (%) Specificity (%) NPV (%) PPV (%) EFF (%) AUC
150 100 96.7 100 94.7 97.9 0.798
GDF-15(ng/L) for discriminating subgroup І (F0–F1) patients from subgroup II (F2) Cut-off Sensitivity (%) Specificity (%) NPV (%) PPV (%) EFF (%) AUC
400 66.7 76.9 80.8 62.5 71.0 0.694
GDF-15(ng/L) for discriminating subgroup І (F0–F1) patients from subgroup III (F3–4) Cut-off Sensitivity (%) Specificity (%) NPV (%) PPV (%) EFF (%) AUC
220 27.8 95.8 83.3 63.9 66.7 0.687
GDF-15(ng/L) for discriminating subgroup II (F2) patients from subgroup III (F3–F4). Cut-off Sensitivity (%) Specificity (%) NPV (%) PPV (%) EFF (%) AUC
420 54.2 69.2 76.5 45.0 59.5 0.508
  1. AUC area under the curve, NPV negative predictive value, PPV positive predictive value, EFF efficiency