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Table 2 Lab investigations of the studied groups

From: Association between miR-196a2 polymorphism and the development of hepatocellular carcinoma in the Egyptian population

 

Control

N = 60

Cirrhosis

N = 60

HCC

N = 80

Kruskal–Wallis

P value

Post hoc

AST(U/L)

 Min-max

10.0–29.00

12.0–226.00

21.0-540.0

85.26

< 0.001

P1 = < 0.001

X ± SD

17.30 ± 4.50

60.56 ± 43.95

124.26 ± 204.04

P2 = 0.02

 Median

17.00

45.50

68.50

P3 = < 0.001

ALT(U/L)

 Min-max

10.00–27.00

11.0–121.00

11.0–379.0

86.56

< 0.001

P1 = < 0.001

X ± SD

18.01 ± 4.81

75.30 ± 18.73

79.32 ± 71.51

P2 = < 0.63

 Median

17.00

54.00

55.00

P3 = < 0.001

Albumin (g/dL)

 Min-max

3.70–5.0

1.0–4.00

2.0–4.0

114.31

< 0.001

P1 = < 0.001

X ± SD

4.42 ± 0.05

1.74 ± 0.09

2.62 ± 0.66

P2 = 0.32

P3 = < 0.001

 Median

4.40

3.00

3.00

Total bilirubin (mg/dl)

 Min-max

.20–.80

1. 2-15.0

1.0–20.00

  

P1 = < 0.001

X ± SD

0.267 ± 0.021

3.20 ± 0.413

3.45 ± 0.38

121.93

< 0.001

P2 = 0.31

 Median

.54

1.20

3.0

P3 = < 0.001

Direct bilirubin (mg/dl)

 Min-max

.06–.20

1.00–11.00

1.00–16.00

51.30

< 0.001

P1 = < 0.001

X ± SD

0.038 ± 0.004

3.22 ± 0.90

3.33 ± 0.37

P2 = 0.30

 Median

.105

1.00

1.50

P3 = < 0.001

Alpha fetoprotein (ng/mL)

 Min-max

-------

1-100

6-20,949

9.78*

< 0.001

----------

X ± SD

 

13.85± 1.78

3770.10 ± 421.51

 Median

 

4.00

526.00

Prothrombin conc.

 Min-max

83–100

40–93

19-102

112.96

< 0.001

P1 = < 0.001

X ± SD

93.67 ± 4.534

56.63 ± 13.467

58.37 ± 16.95

P2 = 0.87

 Median

92.50

50.60

57.40

P3 = < 0.001

PT.INR

 Min-max

1.00–1.11

1.02–1.83

.95–3.59

113.35

< 0.001

P1 = < 0.001

X ± SD

1.03 ± 0.028

1.42 ± 0.18

1.48 ± 0.434

P2 = 0.65

 Median

1.0200

1.43

1.38

P3 = < 0.001

 

No

%

No

%

No

%

   

HCV Ab

 Negative

60

100.0

1

1.7

7

8.8

167.15

< 0.001

 

 Positive

0

0.0

59

98.3

73

91.2

HBV sAg

 Negative

60

100.0

60

100.0

78

97.5

1.96**

0.33

 

 Positive

0

0.0

0

0.0

2

2.5

  1. *Mann–Whitney test
  2. **Fisher’s exact test
  3. • P1 = comparison between cirrhosis and control
  4. • P2 = comparison between cirrhosis and HCC
  5. • P3 = comparison between control and HCC