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Table 5 Comparison between the four studied groups according to genotype distribution of IRS1 G972R (rs 1801278) polymorphism

From: Insulin receptor substrate-1 G972R single nucleotide polymorphism in Egyptian patients with chronic hepatitis C virus infection and type 2 diabetes mellitus

Parameters Group I (n = 50) Group II (n = 50) Group III (n = 52) Group IV (n = 50) χ2 P
N % N % N % N %
IRS1 G972R
 GG Homo wild 35 70.0 23 46.0 24 46.2 21 42.0 12.243* MCP = 0.034*
 GA Hetero 15 30.0 23 46.0 26 50.0 27 54.0
 AA Homo mutant 0 0.0 4 8.0 2 3.8 2 4.0
  Sig. bet. Grps MCP1 = 0.017*, MCP2 = 0.019*, MCP3 = 0.009*, MCP4 = 0.700, MCP5 = 0.627, MCP6 = 0.880   
 G 85 85.0 69 69.0 72 69.2 74 74.0 8.861* 0.031*
 A 15 15.0 31 31.0 32 30.8 26 26.0
  Sig. bet. Grps P1 = 0.007*, P2 = 0.017*, P3 = 0.007, P4 = 0.972, P5 = 0.434, P6 = 0.450   
  1. χ2 chi-square test, MC Monte Carlo, P P value for comparing between the different groups, common letters are not significant (i.e., different letters are significant), P1 P value for comparing between group I and group II, P2 P value for comparing between group I and group III, P3 P value for comparing between group I and group IV, P4 P value for comparing between group II and group III, P5 P value for comparing between group II and group IV, P6 P value for comparing between group III and group IV, Sig. bet. Grps significance between groups
  2. *Statistically significant at P ≤ 0.05