Could insulin receptor H1085H C > T single nucleotide polymorphism predict insulin resistance in type 2 diabetic and chronic hepatitis C virus patients in Egypt?

Egyptian Liver Journal

Table 3 Comparison between the four studied groups according to genotype distribution of INSR H1085H C > T (rs 1799817) polymorphism

Parameters	Group I (n = 50)		Group II (n = 50)		Group III (n = 52)		Group IV (n = 50)		χ²	P
	N	%	N	%	N	%	N	%	χ²	P
INSR H1085H C > T
CC homo wild	30	60.0	5	10.0	24	46.2	20	40.0	84.746*	< 0.001*
CT hetero	20	40.0	14	28.0	25	48.1	25	50.0
TT homo mutant	0	0.0	31	62.0	3	5.8	5	10.0
Sig. bet. Grps	p₁ < 0.001, ^MCp₂ = 0.131, p₃ = 0.018, p₄ < 0.001, p₅ < 0.001, ^MCp₆ = 0.658
C	80	80.0	24	24.0	73	70.2	65	65.0	76.146*	< 0.001*
T	20	20.0	76	76.0	31	29.8	35	35.0	76.146*	< 0.001*
Sig. bet. Grps	p₁ < 0.001, p₂ = 0.106, p₃ = 0.018, p₄ < 0.001, p₅ < 0.001, p₆ = 0.428

χ² chi-square test, MC Monte Carlo, p p value for comparing between the different groups, common letters are not significant (i.e., different letters are significant), p₁ p value for comparing between group I and group II, p₂ p value for comparing between group I and group III, p₃ p value for comparing between group I and group IV, p₄ p value for comparing between group II and group III, p₅ p value for comparing between group II and group IV, p₆ p value for comparing between group III and group IV, Sig. bet. Grps significance between groups
*Statistically significant at p ≤ 0.05