Vitamin D receptor gene polymorphism and hepatocellular carcinoma in chronic hepatitis C patients

Mosaad, Hala; Emam, Emad A.; Hamed, Emad F.; El Demerdash, Ezzat A.; Hussein, Samia

doi:10.1186/s43066-020-00063-7

Egyptian Liver Journal

Table 4 Relation between Apa-1vitamin D receptor genotypes and different parameters in the hepatocellular carcinoma (HCC) group

From: Vitamin D receptor gene polymorphism and hepatocellular carcinoma in chronic hepatitis C patients

Group B (HCC)		Genotype			ANOVA
Group B (HCC)		AA	CA	CC	F	P
Age (years)	Range	44–66	39–60	33–68	0.339	0.715
Age (years)	Mean ± SD	54.000 ± 11.136	51.429 ± 7.161	51.429 ± 7.161	0.339	0.715
T. bilirubin (mg/dl)	Range	0.9–3 1	1.11–4.6	0.9–8.2	0.523	0.598
T. bilirubin (mg/dl)	Mean ± SD	1.723 ± 1.121	1.919 ± 1.222	2.456 ± 1.685	0.523	0.598
D. bilirubin (mg/dl)	Range	0.35–0.61	0.42–1.4	0.087–1.4	1.588	0.221
D. bilirubin (mg/dl)	Mean ± SD	0.520 ± 0.147	0.836 ± 0.299	0.787 ± 0.264	1.588	0.221
ALT (IU/L)	Range	77–133	65–180	68–134	0.125	0.883
ALT (IU/L)	Mean ± SD	98.667 ± 30.072	102.000 ± 39.770	96.458 ± 20.532	0.125	0.883
AST (IU/L)	Range	49–112	62–116	53–119	0.117	0.890
AST (IU/L)	Mean ± SD	72.000 ± 34.771	79.143 ± 17.995	78.000 ± 21.685	0.117	0.890
S. albumin (g/dl)	Range	2.3–3.8	1.8–3.2	1.5–3.9	1.598	0.218
S. albumin (g/dl)	Mean ± SD	3.033 ± 0.751	2.400 ± 0.432	2.908 ± 0.748	1.598	0.218
ALP (IU/L)	Range	94–122	80–156	59–240	0.491	0.616
ALP (IU/L)	Mean ± SD	104.000 ± 15.620	121.714 ± 24.074	105.875 ± 42.470	0.491	0.616
S. Creatinine (mg/dL)	Range	0.65–1.3	0.65–1.8	0.75–1.42	1.625	0.213
S. Creatinine (mg/dL)	Mean ± SD	0.950 ± 0.328	1.199 ± 0.385	1.004 ± 0.219	1.625	0.213
AFP (ng/mL)	Range	70–430	86–1214	430–20834	4.455	0.020^*
AFP (ng/mL)	Mean ± SD	256.667 ± 180.370	447.571 ± 369.296	4936.083 ± 4694.481	4.455	0.020^*
PLT (×103)	Range	134–215	76–200	61–334	1.100	0.346
PLT (×103)	Mean ± SD	181.333 ± 42.194	133.143 ± 48.746	129.708 ± 59.979	1.100	0.346
HGB (g/dL)	Range	12–13.3	10.8–14.6	8.5–17.5	0.137	0.873
HGB (g/dL)	Mean ± SD	12.633 ± 0.651	12.443 ± 1.218	12.192 ± 1.806	0.137	0.873
INR	Range	1.02–1.26	1.18–2.5	1.02–2.7	1.234	0.305
INR	Mean ± SD	1.123 ± 0.123	1.534 ± 0.442	1.369 ± 0.385	1.234	0.305
PT (sec)	Range	12.2–15	14.3–30	12.2–33	1.141	0.332
PT (sec)	Mean ± SD	13.400 ± 1.442	18.457 ± 5.283	16.575 ± 4.981	1.141	0.332
BMI (kg/m2)	Range	22.7–23.5	22.2–23.9	22.1–23.8	0.556	0.579
BMI (kg/m2)	Mean ± SD	23.133 ± 0.404	23.029 ± 0.582	23.242 ± 0.456	0.556	0.579
S.UREA range (ng/l)	Range	27–30	26–43	26–40	1.259	0.298
S.UREA range (ng/l)	Mean ± SD	29.000 ± 1.732	33.143 ± 5.581	31.458 ± 3.413	1.259	0.298
Tumor size	Range	2.5–3	2.5–4.5	2.5–5.5	5.672	0.008^*
Tumor size	Mean ± SD	2.667 ± 0.289	2.943 ± 0.714	3.917 ± 0.903	5.672	0.008^*

^*P-value<0.05 (significant)

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