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Table 4 ROC curve of AFP in the total studied patient

From: Interleukin-18 polymorphism as a diagnostic tumor marker for hepatocellular carcinoma in patients with hepatitis C-related cirrhosis

  Cirrhotic HCC
AUC (95% CI) 0.696 (0.56–0.83) 0.926 (0.85–0.99)
Cutoff point ≥ 3.45 ≥ 4.50
Sensitivity (%) 62.2 84.8
Specificity (%) 75.0 85.0
PPV (%) 82.1 90.3
NPV (%) 51.7 77.3
Accuracy (%) 66.7 84.9
  1. This table shows that the sensitivity and specificity of AFP in HCC patients (84.8% and 85%, respectively) and in the cirrhotic group (62.2% and 75% respectively). The PPV and NPV in the HCC group are 90.3% and 77.3%, respectively, and 82.1% and 51.7%, respectively, in the cirrhotic group
  2. AUC area under the curve, PPV positive predictive value, NPV negative predictive value, P probability