The impact of achieving a sustained virological response with direct-acting antivirals on serum autotaxin levels in chronic hepatitis C patients

Egyptian Liver Journal

Table 5 The diagnostic performance for the detection of grade F3–4 fibrosis at SVR12

Criterion	Cutoff value	AUC	Se (%)	Sp (%)	PPV	NPV	95% confidence intervals		p value
Criterion	Cutoff value	AUC	Se (%)	Sp (%)	PPV	NPV	Upper	Lower	p value
ATX	≥ 381 pg/mL	0.579	52.9	36.6	0.344	0.578	0.378	0.728	0.186
FIB4	≥ 1.11	0.715	70.5	36.6	0.406	0.687	0.517	0.840	0.003
APRI score	≥ 0.24	0.645	76.4	50	0.464	0.789	0.458	0.778	0.035

ATX autotaxin, APRI AST-to-Platelet Ratio Index, AUC area under the curve, NPV negative predictive value, PPV positive predictive value, Se sensitivity, Sp specificity