The impact of achieving a sustained virological response with direct-acting antivirals on serum autotaxin levels in chronic hepatitis C patients

Egyptian Liver Journal

Table 4 The diagnostic performance for the detection of grade F3–4 fibrosis at baseline

Criterion	Cutoff value	AUC	Se (%)	Sp (%)	PPV	NPV	95% confidence limits		p value
Criterion	Cutoff value	AUC	Se (%)	Sp (%)	PPV	NPV	Upper	Lower	p value
ATX	≥ 448 pg/mL	0.520	65.3	42.8	0.586	0.500	0.331	0.668	0.407
FIB4	≥ 1.26	0.895	96.1	61.9	0.757	0.928	0.766	0.955	< 0.001
APRI	≥ 0.32	0.858	96.1	61.9	0.757	0.928	0.705	0.934	< 0.001

ATX autotaxin, APRI AST-to-Platelet Ratio Index, AUC area under the curve, NPV negative predictive value, PPV positive predictive value, Se sensitivity, Sp specificity