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Table 1 Patients’ characteristics at baseline and SVR12

From: The impact of achieving a sustained virological response with direct-acting antivirals on serum autotaxin levels in chronic hepatitis C patients

 

Baseline (n = 48)

SVR12 (n = 47)

p value

ATX (pg/mL)

500.5 (399.5–667.5)

404 (331–518)

< 0.001

ALT (IU/L)

42 (28–54)

21 (17–25)

< 0.001

AST (IU/L)

36.50 (29–49)

21 (19–25)

< 0.001

Albumin (mg/dL)

4.31 ± 0.60

4.47 ± 0.48

0.005

Creatinine (mg/dL)

0.86 ± 0.21

0.94 ± 0.14

< 0.001

Total bilirubin (mg/dL)

0.80 (0.6–1)

0.85 (0.7–1)

0.088

WBC (×103/μL)

6.48 (5.4–8)

5.60 (4.68–6.50)

0.007

Platelets (g/dL)

203.7 ± 82.83

204.9 ± 53.67

0.860

Hemoglobin (g/dL)

13.37 ± 1.63

13.15 ± 1.55

0.331

INR

1.07 ± 0.14

1.05 ± 0.11

0.009

AFP (ng/mL)

5.20 ± 1.0

4.52 ± 0.71

< 0.001

MELD score

7.45 ± 1.76

7.12 ± 1.43

0.045

Child-Pugh score

5.20 ± 0.41

5.10 ± 0.31

0.095

APRI score

0.46 (0.28–0.92)

0.25 (0.21–0.34)

< 0.001

FIB4 score

1.63 (1.13–3.22)

1.29 (1.03–1.69)

< 0.001

LS (kPa)

10.30 (7.15–14.45)

8.80 (6.70–11.60)

< 0.001

  1. AFP alpha-fetoprotein, ALT alanine aminotransferase, APRI AST-to-Platelet Ratio Index, AST aspartate aminotransferase, ATX autotaxin, INR international normalized ratio, LS liver stiffness, MELD Model for End-Stage Liver Disease, WBC white blood cell count