The role of serum bile acid profile in differentiation between nonalcoholic fatty liver disease and chronic viral hepatitis

Egyptian Liver Journal

Table 3 Sensitivity, specificity, and diagnostic accuracy of serum bile acids levels to distinguish viral hepatitis from NAFLD

Viral hepatitis (group 2) versus NAFLD (group 3)
	AUC	p	95% C.I	Cutoff	Sensitivity	Specificity	PPV	NPV
TCA	0.749*	< 0.001*	0.68–0.81	> 0.001	54.11	92.31	96.3	35.0
TCDCA	0.627*	0.003*	0.55–0.70	> 0.02	60.96	56.41	84.0	27.8
TUDCA	0.608*	0.006*	0.55–0.70	> 0	59.59	43.59	79.8	22.4
TLCA	0.575	0.108	0.50–0.65	> 0	66.44	43.59	81.5	25.8
GCA	0.657	0.006*	0.58–0.73	> 0.35	51.37	64.10	84.3	26.0
GCDCA	0.667	0.001*	0.59–0.73	> 1.1	50.0	76.92	89.0	29.1
UDCA	0.570	0.182	0.45–0.69	> 0	75.34	51.28	85.3	35.7
DCA	0.602	0.049*	0.49–0.71	> 0.04	81.51	43.59	84.4	38.6
LCA	0.769	< 0.001*	0.70–0.83	> 0	58.22	92.31	96.6	37.1

AUC area under a curve, p value probability value, CI confidence intervals, NPV negative predictive value, PPV positive predictive value, CDCA chenodeoxycholic acid, TCA taurocholic acid, TCDCA taurochenodeoxycholic acid, TUDCA taurodeoxycholic acid, TLCA taurolithocholic acid, GCA glycholic acid, GCDCA glycochenodeoxycholic acid, UDCA ursodeoxycholic acid, DCA deoxycholic acid, LCA lithocholic acid
*Statistically significant at p < 0.05