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Table 2 Comparison of 14 bile acid composition among the three studied groups

From: The role of serum bile acid profile in differentiation between nonalcoholic fatty liver disease and chronic viral hepatitis

  Control (n = 51) Viral hepatitis (HBV + HCV) (n = 146) NAFLD (n = 39) p Significance between groups
I vs. II I vs. III II vs. III
CA (μmol/l)
 Min.–Max. 0.0–1.500 0.0–7.400 0.0–4.200 0.006* 0.003* 0.007* 0.585
 Median 0.100 0.200 0.200
CDCA (μmol/l)
 Min.–Max. 0.0–2.500 0.0–8.500 0.020–5.300 0.001* < 0.001* 0.002* 0.699
 Median 0.200 0.400 0.600
TCA (μmol/l)
 Min.–Max. 0.0–0.400 0.0–10.500 0.0–0.100 < 0.001* < 0.001* 0.288 < 0.001*
 Median 0.0 0.010 0.0
TCDCA (μmol/l)
 Min.–Max. 0.0–0.900 0.0–71.0 0.0–0.900 0.004* 0.006* 0.943 0.016*
 Median 0.020 0.070 0.020
TUDCA (μmol/l)
 Min.–Max. 0.0–0.800 0.0–2.600 0.0–0.030 0.091 ? ? ?
 Median 0.001 0.001 0.001
TDCA (μmol/l)
 Min.–Max. 0.0–0.700 0.0–1.0 0.0–0.300 0.495 ? ? ?
 Median 0.001 0.001 0.001
TLCA (μmol/l)
 Min.–Max. 0.0–0.200 0.0–0.300 0.0–0.030 0.008* 0.003* 0.296 0.138
 Median 0.0 0.001 0.001
GCA (μmol/l)     < 0.001* < 0.001* 0.351 0.003*
 Min.–Max. 0.0–1.500 0.0–13.0 0.0–5.0
 Median 0.100 0.400 0.120
GCDCA (μmol/l)     < 0.001* < 0.001* 0.011* 0.002*
 Min.–Max. 0.0–2.800 0.060–58.300 0.0–2.500
 Median 0.120 1.150 0.500
GUDCA (μmol/l)     0.624 ? ? ?
 Min.–Max. 0.0–1.100 0.0–63.600 0.0–1.600
 Median 0.100 0.100 0.100
GDCA (μmol/l)     0.001* 0.002* 0.916 0.006*
 Min.–Max. 0.0–1.900 0.0–13.400 0.0–1.300
 Median 0.100 0.215 0.100
UDCA (μmol/l)
 Min.–Max. 0.0–0.500 0.0–26.300 0.0–7.500 0.003* 0.001* 0.205 0.133
 Median 0.001 0.030 0.0
DCA (μmol/l)
 Min.–Max. 0.0–0.530 0.0–1.430 0.0–0.800 0.016* 0.016* 0.920 0.039*
 Median 0.100 0.200 0.110
LCA (μmol/l)
 Min.–Max. 0.0–0.200 0.0–0.340 0.0–0.020 < 0.001* < 0.001* < 0.001* 0.071
 Median 0.0 0.006 0.0
  1. Min. minimum, Max. maximum, CA cholic acid, CDCA chenodeoxycholic acid, TCA taurocholic acid, TCDCA taurochenodeoxycholic acid, TUDCA tauroursoodeoxycholic acid, TDCA taurodeoxycholic acid, TLCA taurolithocholic acid, GCA glycholic acid, GCDCA glycochenodeoxycholic acid, GUDCA glycoursodeoxycholic acid, GDCA glycodeoxycholic acid, UDCA ursodeoxycholic acid, DCA deoxycholic acid, LCA lithocholic acid, Vs. versus
  2. H: H for Kruskal-Wallis test, pairwise comparison between each 2 groups was done using post hoc test (Dunn’s for multiple comparisons test) p: p value for comparing between the studied groups
  3. *Statistically significant at p < 0.05