The role of serum bile acid profile in differentiation between nonalcoholic fatty liver disease and chronic viral hepatitis

Elsheashaey, Azza; Obada, Manar; Abdelsameea, Eman; Bayomy, Mohamed F. F.; El-Said, Hala

doi:10.1186/s43066-020-00057-5

Egyptian Liver Journal

Table 2 Comparison of 14 bile acid composition among the three studied groups

From: The role of serum bile acid profile in differentiation between nonalcoholic fatty liver disease and chronic viral hepatitis

	Control (n = 51)	Viral hepatitis (HBV + HCV) (n = 146)	NAFLD (n = 39)	p	Significance between groups
	Control (n = 51)	Viral hepatitis (HBV + HCV) (n = 146)	NAFLD (n = 39)	p	I vs. II	I vs. III	II vs. III
CA (μmol/l)
Min.–Max.	0.0–1.500	0.0–7.400	0.0–4.200	0.006*	0.003*	0.007*	0.585
Median	0.100	0.200	0.200	0.006*	0.003*	0.007*	0.585
CDCA (μmol/l)
Min.–Max.	0.0–2.500	0.0–8.500	0.020–5.300	0.001*	< 0.001*	0.002*	0.699
Median	0.200	0.400	0.600	0.001*	< 0.001*	0.002*	0.699
TCA (μmol/l)
Min.–Max.	0.0–0.400	0.0–10.500	0.0–0.100	< 0.001*	< 0.001*	0.288	< 0.001*
Median	0.0	0.010	0.0	< 0.001*	< 0.001*	0.288	< 0.001*
TCDCA (μmol/l)
Min.–Max.	0.0–0.900	0.0–71.0	0.0–0.900	0.004*	0.006*	0.943	0.016*
Median	0.020	0.070	0.020	0.004*	0.006*	0.943	0.016*
TUDCA (μmol/l)
Min.–Max.	0.0–0.800	0.0–2.600	0.0–0.030	0.091	?	?	?
Median	0.001	0.001	0.001	0.091	?	?	?
TDCA (μmol/l)
Min.–Max.	0.0–0.700	0.0–1.0	0.0–0.300	0.495	?	?	?
Median	0.001	0.001	0.001	0.495	?	?	?
TLCA (μmol/l)
Min.–Max.	0.0–0.200	0.0–0.300	0.0–0.030	0.008*	0.003*	0.296	0.138
Median	0.0	0.001	0.001	0.008*	0.003*	0.296	0.138
GCA (μmol/l)				< 0.001*	< 0.001*	0.351	0.003*
Min.–Max.	0.0–1.500	0.0–13.0	0.0–5.0
Median	0.100	0.400	0.120
GCDCA (μmol/l)				< 0.001*	< 0.001*	0.011*	0.002*
Min.–Max.	0.0–2.800	0.060–58.300	0.0–2.500
Median	0.120	1.150	0.500
GUDCA (μmol/l)				0.624	?	?	?
Min.–Max.	0.0–1.100	0.0–63.600	0.0–1.600
Median	0.100	0.100	0.100
GDCA (μmol/l)				0.001*	0.002*	0.916	0.006*
Min.–Max.	0.0–1.900	0.0–13.400	0.0–1.300
Median	0.100	0.215	0.100
UDCA (μmol/l)
Min.–Max.	0.0–0.500	0.0–26.300	0.0–7.500	0.003*	0.001*	0.205	0.133
Median	0.001	0.030	0.0	0.003*	0.001*	0.205	0.133
DCA (μmol/l)
Min.–Max.	0.0–0.530	0.0–1.430	0.0–0.800	0.016*	0.016*	0.920	0.039*
Median	0.100	0.200	0.110	0.016*	0.016*	0.920	0.039*
LCA (μmol/l)
Min.–Max.	0.0–0.200	0.0–0.340	0.0–0.020	< 0.001*	< 0.001*	< 0.001*	0.071
Median	0.0	0.006	0.0	< 0.001*	< 0.001*	< 0.001*	0.071

Min. minimum, Max. maximum, CA cholic acid, CDCA chenodeoxycholic acid, TCA taurocholic acid, TCDCA taurochenodeoxycholic acid, TUDCA tauroursoodeoxycholic acid, TDCA taurodeoxycholic acid, TLCA taurolithocholic acid, GCA glycholic acid, GCDCA glycochenodeoxycholic acid, GUDCA glycoursodeoxycholic acid, GDCA glycodeoxycholic acid, UDCA ursodeoxycholic acid, DCA deoxycholic acid, LCA lithocholic acid, Vs. versus
H: H for Kruskal-Wallis test, pairwise comparison between each 2 groups was done using post hoc test (Dunn’s for multiple comparisons test) p: p value for comparing between the studied groups
*Statistically significant at p < 0.05

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