| |
Control (n = 51)
|
Viral hepatitis (HBV + HCV) (n = 146)
|
NAFLD (n = 39)
|
p
|
Significance between groups
|
|---|
|
I vs. II
|
I vs. III
|
II vs. III
|
|---|
|
CA (μmol/l)
|
|
Min.–Max.
|
0.0–1.500
|
0.0–7.400
|
0.0–4.200
|
0.006*
|
0.003*
|
0.007*
|
0.585
|
|
Median
|
0.100
|
0.200
|
0.200
|
|
CDCA (μmol/l)
|
|
Min.–Max.
|
0.0–2.500
|
0.0–8.500
|
0.020–5.300
|
0.001*
|
< 0.001*
|
0.002*
|
0.699
|
|
Median
|
0.200
|
0.400
|
0.600
|
|
TCA (μmol/l)
|
|
Min.–Max.
|
0.0–0.400
|
0.0–10.500
|
0.0–0.100
|
< 0.001*
|
< 0.001*
|
0.288
|
< 0.001*
|
|
Median
|
0.0
|
0.010
|
0.0
|
|
TCDCA (μmol/l)
|
|
Min.–Max.
|
0.0–0.900
|
0.0–71.0
|
0.0–0.900
|
0.004*
|
0.006*
|
0.943
|
0.016*
|
|
Median
|
0.020
|
0.070
|
0.020
|
|
TUDCA (μmol/l)
|
|
Min.–Max.
|
0.0–0.800
|
0.0–2.600
|
0.0–0.030
|
0.091
|
?
|
?
|
?
|
|
Median
|
0.001
|
0.001
|
0.001
|
|
TDCA (μmol/l)
|
|
Min.–Max.
|
0.0–0.700
|
0.0–1.0
|
0.0–0.300
|
0.495
|
?
|
?
|
?
|
|
Median
|
0.001
|
0.001
|
0.001
|
|
TLCA (μmol/l)
|
|
Min.–Max.
|
0.0–0.200
|
0.0–0.300
|
0.0–0.030
|
0.008*
|
0.003*
|
0.296
|
0.138
|
|
Median
|
0.0
|
0.001
|
0.001
|
|
GCA (μmol/l)
| | | |
< 0.001*
|
< 0.001*
|
0.351
|
0.003*
|
|
Min.–Max.
|
0.0–1.500
|
0.0–13.0
|
0.0–5.0
|
|
Median
|
0.100
|
0.400
|
0.120
|
|
GCDCA (μmol/l)
| | | |
< 0.001*
|
< 0.001*
|
0.011*
|
0.002*
|
|
Min.–Max.
|
0.0–2.800
|
0.060–58.300
|
0.0–2.500
|
|
Median
|
0.120
|
1.150
|
0.500
|
|
GUDCA (μmol/l)
| | | |
0.624
|
?
|
?
|
?
|
|
Min.–Max.
|
0.0–1.100
|
0.0–63.600
|
0.0–1.600
|
|
Median
|
0.100
|
0.100
|
0.100
|
|
GDCA (μmol/l)
| | | |
0.001*
|
0.002*
|
0.916
|
0.006*
|
|
Min.–Max.
|
0.0–1.900
|
0.0–13.400
|
0.0–1.300
|
|
Median
|
0.100
|
0.215
|
0.100
|
|
UDCA (μmol/l)
|
|
Min.–Max.
|
0.0–0.500
|
0.0–26.300
|
0.0–7.500
|
0.003*
|
0.001*
|
0.205
|
0.133
|
|
Median
|
0.001
|
0.030
|
0.0
|
|
DCA (μmol/l)
|
|
Min.–Max.
|
0.0–0.530
|
0.0–1.430
|
0.0–0.800
|
0.016*
|
0.016*
|
0.920
|
0.039*
|
|
Median
|
0.100
|
0.200
|
0.110
|
|
LCA (μmol/l)
|
|
Min.–Max.
|
0.0–0.200
|
0.0–0.340
|
0.0–0.020
|
< 0.001*
|
< 0.001*
|
< 0.001*
|
0.071
|
|
Median
|
0.0
|
0.006
|
0.0
|
- Min. minimum, Max. maximum, CA cholic acid, CDCA chenodeoxycholic acid, TCA taurocholic acid, TCDCA taurochenodeoxycholic acid, TUDCA tauroursoodeoxycholic acid, TDCA taurodeoxycholic acid, TLCA taurolithocholic acid, GCA glycholic acid, GCDCA glycochenodeoxycholic acid, GUDCA glycoursodeoxycholic acid, GDCA glycodeoxycholic acid, UDCA ursodeoxycholic acid, DCA deoxycholic acid, LCA lithocholic acid, Vs. versus
- H: H for Kruskal-Wallis test, pairwise comparison between each 2 groups was done using post hoc test (Dunn’s for multiple comparisons test) p: p value for comparing between the studied groups
- *Statistically significant at p < 0.05
