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Table 3 Genotype distribution among the studied groups

From: Association of IL-10 and TNF-α polymorphisms with risk and aggressiveness of hepatocellular carcinoma in patients with HCV-related cirrhosis

 

HCC, n = 73 (%)

Cirrhotic, n = 85 (%)

Test of significance

Odds ratio (95% CI)

IL-10

 TT/AA

29 (39.7%)

16 (18.8%)

χ2 = 8.2, P = 0.004*

χ2 = 0.35, P = 0.55

3.15 (1.42–6.99)

 CT/CA

21 (28.8%)

29 (34.1%)

1.26 (0.59–2.69)

 CC/CC

23 (31.5%)

40 (47.1%)

Reference group

Hardy-Weinberg equation

P = 0.002*

P = 0.02*

  

TNF-ɑ

 GG

35 (47.9%)

27 (31.8%)

χ2 = 6.24,

2.67 (1.22–5.83)

 GA

22 (30.1%)

25 (29.4%)

P = 0.01*

1.82 (0.79–4.15)

 AA

16 (21.9%)

33 (38.8%)

χ2 = 2.01, P = 0.16

Reference group

Hardy-Weinberg equation

P = 0.002*

P = 0.001*

  
  1. χ2 chi-square test
  2. *Statistically significant