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Table 2 Association of vitamin D supplementation with different demographic, laboratory, and metabolic parameters of patients with NASH

From: Association of vitamin D supplementation with serum leptin and metabolic parameters in Egyptian patients with non-alcoholic steatohepatitis: a prospective study

Characteristics

Before treatment

After treatment

t value

p value

Significance

Weight (kg)

106.3 ± 15.6

106.0 ± 15.9

0.0924

0.9266

NS

BMI (kg/m2)

35.7 ± 5.7

35.6 ± 5.7

0.0901

0.9284

NS

DBP (mmHg)

94.3 ± 11.9

91.5 ± 11.5

1.0553

0.2946

NS

HbA1c (%)

8.0 ± 2.4

6.8 ± 1.3

2.8558

0.0055

S

Hemoglobin (gm/dL)

13.5 ± 1.5

13.3 ± 1.2

0.6176

0.5386

NS

Platelet (× 103/μL)

288.5 ± 114.9

285.2 ± 98.3

0.1412

0.8881

NS

FBS (mg/dL)

165.6 ± 62.0

136.1 ± 32.7

2.6637

0.0094

S

Fasting insulin (μU/ml)

24.2 ± 3.0

22.9 ± 1.8

2.3090

0.0236

S

HOMA-IR

1.8 ± 0.7

1.4 ± 0.4

3.1134

0.0026

S

Creatinine (mg/dL)

0.9 ± 0.2

0.9 ± 0.3

0.2439

0.8080

NS

ALT (U/L)

78.2 ± 36.7

55.3 ± 21.3

3.4135

0.0010

S

AST (U/L)

108.6 ± 85.6

73.1 ± 54.2

2.2143

0.0297

S

Albumin (gm/dL)

3.8 ± 0.8

4.2 ± 0.7

2.2273

0.0288

S

NAFLD fibrosis score

− 0.78 ± 0.9

− 0.9 ± 1.1

0.9934

0.3236

NS

TCHOL (mg/dL)

233.0 ± 40.9

226.5 ± 38.2

0.7431

0.4596

NS

LDL (mg/dL)

117.5 ± 41.6

129.8 ± 34.7

1.4286

0.1571

NS

HDL (mg/dL)

48.5 ± 7.59

48.1 ± 8.1

0.1858

0.8531

NS

Triglycerides (mg/dL)

229.7 ± 62.1

203.6 ± 49.8

2.0728

0.0415

S

ALP (mg/dL)

70.4 ± 7.3

63.7 ± 7.9

3.9422

0.0002

S

GGT (U/L)

43.3 ± 24.5

35.1 ± 8.7

2.0069

0.0482

S

Total bilirubin (mg/dL)

1.1 ± 0.4

1.1 ± 0.1

0.2267

0.8212

NS

Vitamin D (ng/ml)

15.6 ± 6.6

33.0 ± 7.6

11.0335

<0.0001

S

Leptin (ng/ml)

35.9 ± 28.4

23.5 ± 12.9

2.5129

0.0140

S