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Egyptian Liver Journal
Fig. 3 | Egyptian Liver Journal

Fig. 3

From: The role of hepatic transcription factor cAMP response element-binding protein (CREB) during the development of experimental nonalcoholic fatty liver: a biochemical and histomorphometric study

Fig. 3

a–c Photomicrographs of rat liver of control group showing normal liver architecture where cords of hepatocytes (orange arrows) radiating from central vein (CV). Hepatocytes are polyhedral in shape with vesicular nuclei and slightly vacuolated acidophilic granular cytoplasm. The hepatic cords are separated by blood sinusoids. Portal tract (PT) at the periphery of the hepatic lobule showing its three components, a branch of the portal vein, a branch of the hepatic artery, and a bile duct, is enclosed by a scanty amount of connective tissue. d–l Photomicrographs of rat liver of NAFLD group at different time intervals of HFD induction (6th, 10th, and 14th week) showing a disturbed liver architecture. Hepatocytes show micro- (thin black arrows), macro-vesicular steatosis (thin blue arrows), ballooning degeneration with rarefied cytoplasm (black arrowheads), and Mallory Denk bodies (blue arrowheads). Lobular and periportal cellular infiltrates are seen (thin green arrows) Notice periportal and bridging fibrosis (thick black arrows)

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