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Table 1 Brief summary of four main GWAS in HCV-related HCC

From: Main insights of genome wide association studies into HCV-related HCC

Study/year Ethnicity Cases/controls Discovered SNPs Gene/Chr. P value OR (95%CI)
Kumar 2011 [5] Japanese Discovery stage: 721 HCV-HCC/2890 healthy controls
Replication stage: 673 HCC/2596 healthy controls
rs2596542 MICA/6p21.33 4.2 × 10-13 1.39 (1.27–1.52)
Miki 2011 [6] Japanese Discovery stage: 212 HCC-HCV/765 chronic HCV without HCC
Replication stage: 710 HCC-HCV and 1625 chronic HCV patients
rs1012068 DEPDC5/chr. 22 1 × 10-13 1.75 (1.51–2.03)
Matsuura 2017 [7] Japanese Discovery stage: cohort group of HCV patients with INF-SVR.
123 developed HCC/333 did not develop HCC.
Replication stage: 130 develop HCC/356 did not develop HCC
rs17047200 TLL1/Chr.4 3 × 10-8 2.37 (1.74–3.23)
Lee 2018 [8] Taiwan Discovery stage: 502 HCV-HCC/749 HCV non-HCC controls.
1st replication stage: 669 HCC cases/16000 healthy controls
2nd replication stage 2: 669 HCC cases/429 HCV patients
rs2856723 HLA-DQB1/chr.6 2.58 × 10-43 2.68 (2.32–3.09)
  1. HCV hepatitis C virus, HCC hepatocellular carcinoma, INF-SVR patients received interferon and reached sustained viral response