Table 1 Brief summary of four main GWAS in HCV-related HCC

Kumar 2011 [5]

Japanese

Discovery stage: 721 HCV-HCC/2890 healthy controls

Replication stage: 673 HCC/2596 healthy controls

rs2596542

MICA/6p21.33

4.2 × 10^-13

1.39 (1.27–1.52)

Miki 2011 [6]

Japanese

Discovery stage: 212 HCC-HCV/765 chronic HCV without HCC

Replication stage: 710 HCC-HCV and 1625 chronic HCV patients

rs1012068

DEPDC5/chr. 22

1 × 10^-13

1.75 (1.51–2.03)

Matsuura 2017 [7]

Japanese

Discovery stage: cohort group of HCV patients with INF-SVR.

123 developed HCC/333 did not develop HCC.

Replication stage: 130 develop HCC/356 did not develop HCC

rs17047200

TLL1/Chr.4

3 × 10^-8

2.37 (1.74–3.23)

Lee 2018 [8]

Taiwan

Discovery stage: 502 HCV-HCC/749 HCV non-HCC controls.

1st replication stage: 669 HCC cases/16000 healthy controls

2nd replication stage 2: 669 HCC cases/429 HCV patients

rs2856723

HLA-DQB1/chr.6

2.58 × 10^-43

2.68 (2.32–3.09)